diff --git a/drivers/gpu/drm/panthor/panthor_gpu.c b/drivers/gpu/drm/panthor/panthor_gpu.c
index 5e2c3173ae27..db69449a5be0 100644
--- a/drivers/gpu/drm/panthor/panthor_gpu.c
+++ b/drivers/gpu/drm/panthor/panthor_gpu.c
@@ -35,6 +35,9 @@ struct panthor_gpu {
 
 	/** @reqs_acked: GPU request wait queue. */
 	wait_queue_head_t reqs_acked;
+
+	/** @cache_flush_lock: Lock to serialize cache flushes */
+	struct mutex cache_flush_lock;
 };
 
 #define GPU_INTERRUPTS_MASK	\
@@ -110,6 +113,7 @@ int panthor_gpu_init(struct panthor_device *ptdev)
 
 	spin_lock_init(&gpu->reqs_lock);
 	init_waitqueue_head(&gpu->reqs_acked);
+	mutex_init(&gpu->cache_flush_lock);
 	ptdev->gpu = gpu;
 
 	dma_set_max_seg_size(ptdev->base.dev, UINT_MAX);
@@ -258,6 +262,9 @@ int panthor_gpu_flush_caches(struct panthor_device *ptdev,
 	bool timedout = false;
 	unsigned long flags;
 
+	/* Serialize cache flush operations. */
+	guard(mutex)(&ptdev->gpu->cache_flush_lock);
+
 	spin_lock_irqsave(&ptdev->gpu->reqs_lock, flags);
 	if (!drm_WARN_ON(&ptdev->base,
 			 ptdev->gpu->pending_reqs & GPU_IRQ_CLEAN_CACHES_COMPLETED)) {