diff --git a/arch/s390/boot/Makefile b/arch/s390/boot/Makefile
index 070c9b2e905f..526ed20b9d31 100644
--- a/arch/s390/boot/Makefile
+++ b/arch/s390/boot/Makefile
@@ -3,11 +3,13 @@
 # Makefile for the linux s390-specific parts of the memory manager.
 #
 
+# Tooling runtimes are unavailable and cannot be linked for early boot code
 KCOV_INSTRUMENT := n
 GCOV_PROFILE := n
 UBSAN_SANITIZE := n
 KASAN_SANITIZE := n
 KCSAN_SANITIZE := n
+KMSAN_SANITIZE := n
 
 KBUILD_AFLAGS := $(KBUILD_AFLAGS_DECOMPRESSOR)
 KBUILD_CFLAGS := $(KBUILD_CFLAGS_DECOMPRESSOR)