diff --git a/drivers/mtd/nand/spi/core.c b/drivers/mtd/nand/spi/core.c
index 8bf9301f25e7..bea352dd82d7 100644
--- a/drivers/mtd/nand/spi/core.c
+++ b/drivers/mtd/nand/spi/core.c
@@ -281,8 +281,26 @@ static int spinand_init_cfg_cache(struct spinand_device *spinand)
 static int spinand_init_quad_enable(struct spinand_device *spinand,
 				    bool enable)
 {
-	return spinand_upd_cfg(spinand, CFG_QUAD_ENABLE,
-			       enable ? CFG_QUAD_ENABLE : 0);
+	struct nand_device *nand = spinand_to_nand(spinand);
+	unsigned int target;
+	int ret;
+
+	/*
+	 * QE is a per-die setting on some devices. Program each target
+	 * individually when enabling or disabling quad I/O mode.
+	 */
+	for (target = 0; target < nand->memorg.ntargets; target++) {
+		ret = spinand_select_target(spinand, target);
+		if (ret)
+			return ret;
+
+		ret = spinand_upd_cfg(spinand, CFG_QUAD_ENABLE,
+				      enable ? CFG_QUAD_ENABLE : 0);
+		if (ret)
+			return ret;
+	}
+
+	return 0;
 }
 
 static int spinand_ecc_enable(struct spinand_device *spinand,